Switching from Mounjaro to Wegovy
Why Hundreds Are Switching in 2025
From September 2025, the monthly cost of Mounjaro® (tirzepatide) will rise to £160–£320 per pen, compared to the significantly lower prices at launch.
This sharp increase has left many patients asking:
“Can I afford to stay on Mounjaro?”
“Should I switch to a more cost-effective option like Wegovy (semaglutide)?”
The good news: yes, you can switch from Mounjaro to Wegovy but it must be done safely under medical supervision.
What Are Mounjaro and Wegovy?
Mounjaro (Tirzepatide)
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Dual action: targets both GLP-1 and GIP receptors
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Strong appetite suppression & improved blood sugar control
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Clinical trials show average body weight loss up to 22.5% over 72 weeks
Wegovy (Semaglutide)
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Targets GLP-1 receptors only
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Licensed in the UK for obesity and cardiovascular protection
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STEP trials show 15–21% body weight loss
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A new 7.2mg dose is expected in late 2025, with results potentially matching Mounjaro
Both treatments are once-weekly injections, prescribed alongside healthy diet and lifestyle changes.
Can You Switch from Mounjaro to Wegovy?
Yes, but only under medical supervision.
You cannot inject both drugs together, and doses are not directly interchangeable. The safe switch looks like this:
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Take your final Mounjaro dose as usual.
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Wait 7 days (washout period).
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Restart Wegovy at 0.25mg weekly.
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Titrate slowly every 4 weeks: 0.5mg, 1mg, 1.7mg, 2.4mg.
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Higher doses (7.2mg) may become available in late 2025.
Mounjaro vs Wegovy: At a Glance
Mounjaro vs. Wegovy – Which is Right for You?
| Mounjaro (Tirzepatide) | Wegovy (Semaglutide) | |
 |  |
|
| Weekly injection | Yes once a week dose | Yes once a week dose |
| Clinical weight loss | 20%+ weight loss in trials | 15%+ weight loss in trials |
| Cost after Sept 2025 | Higher | Likely lower than Mounjaro |
| Availability | Good | Good |
Why Can’t You Switch Dose for Dose?
Although both belong to the GLP-1 medicine family, their strength and action differ:
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Mounjaro: Dual action (GLP-1 + GIP), stronger potency
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Wegovy: GLP-1 only
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Different half-lives: meaning they stay in the body for different lengths of time
Switching mg-for-mg could cause severe nausea, vomiting, or side effects.
Think of it like moving from spirits to wine, you can’t just match the same measure.
What Results Can You Expect After Switching?
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Short pause in weight loss: A 2–3 week plateau is normal.
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Better tolerance: Wegovy often has fewer side effects.
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Comparable long-term results: Up to 21% weight loss.
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Added benefit: Wegovy offers unique cardiovascular protection.
Who Shouldn’t Switch?
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Pregnant or breastfeeding women
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History of pancreatitis
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Severe gastrointestinal disease
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Allergy to semaglutide
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Current use of another GLP-1 medicine
Do We Recommend Switching Only Because of Price?
No. At Puri Pharmacy, we never push patients to change treatment based on cost alone.
Every consultation is personalised to you considering your:
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Medical history and current health conditions
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Weight loss progress so far
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Side effect profile and tolerance
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Lifestyle and long-term health goals
While rising prices may prompt many patients to explore alternatives, our role is to ensure you receive the most effective, safe, and sustainable treatment for your individual needs.
Some patients will remain on Mounjaro, others may transition to Wegovy, but the decision is always made together with you.
