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The Next Wave of Weight Loss Drugs

If you’ve heard of Wegovy or Mounjaro, you know that weight loss drugs are changing what’s possible for people struggling with their weight. Now, a new wave of weight loss medications is on the horizon.

This article will introduce six emerging therapies and explain how they might help with weight loss, how they work, and when they could become available.

    • Retatrutide
    • Amycretin
    • CagriSema
    • Orforglipron
    • MariTide
    • GSBR-1290

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This post has been verified by a clinical specialist.

Verified by Rahul Puri on 16 June 2025

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South Asian man self-administering a Retatrutide style injection using a beige and blue pen injector, representing personal use of experimental triple-action weight loss medication

A “Triple Hormone” Weight Loss Shot

Retatrutide

What is Retatrutide?

Retatrutide is a new weight loss injection that’s currently being tested and showing very promising results. It’s made by the same company that created Mounjaro, and it works by copying three natural hormones your body already makes to help control hunger, how much you eat, and how your body uses energy.

What is a hormone?

Hormones are chemical messengers made by your body. They travel in your blood and tell different parts of your body what to do, for example, when to feel hungry, how to burn calories, or how to manage blood sugar. Think of hormones like text messages your body sends to keep everything running smoothly.

How does Retatrutide work?

Most current weight loss injections copy one or two hormones (like GLP-1 and GIP). Retatrutide goes one step further by also copying a third hormone called glucagon. Together, they:

  • Help you feel full quicker

  • Reduce how much you eat

  • Increase how many calories your body burns

How effective is it?

In a recent study, people using Retatrutide lost up to 24% of their body weight in 11 months,  the highest result ever seen from a weight loss medication.

To give you an idea:

  • Wegovy (semaglutide) helps with about 15% weight loss

  • Mounjaro (tirzepatide) helps with about 20%

Retatrutide is showing even greater results in early trials.

Are there other health benefits?

Yes. People taking Retatrutide in the study also had better:

  • Blood sugar control

  • Blood pressure levels

When will it be available?

Right now, Retatrutide is still being tested in large clinical trials. These are needed to check that it’s safe and works well. If everything goes to plan, it might be approved around 2026–2027.

For now, it’s not available to the public, only people in research studies can access it.

Woman shown with a glowing stomach illustration, standing beside a healthy plate of food, next to a pill and injection pen—representing how Amycretin targets hunger through two hormones.

Dual-Action (GLP-1 + Amylin) Therapy

Amycretin

What is Amycretin?

Amycretin is a new weight loss treatment being tested by the makers of Wegovy. It may be available in the future as a weekly injection or a daily pill.

How does Amycretin work?

It copies two natural substances in your body called hormones.

Hormones are chemical messengers that help control how hungry you feel and how your body handles food.

Amycretin targets:

  • GLP-1 – helps reduce your appetite (makes you feel full)

  • Amylin – slows how fast food leaves your stomach, helping you stay full longer

Together, they help you eat less and feel more satisfied after meals.

How effective is it?

  • People using the injection lost about 22% of their body weight in 9 months

  • People using the pill lost over 13% in just 3 months

Are there other health benefits?

It may also help with blood sugar control (important for people with or at risk of diabetes), but more research is needed.

When will it be available?

It’s still in early testing, but if things go well, Amycretin could be available by the late 2020s.

A Powerful Combo of Two Drugs

CagriSema

What is CagriSema?

CagriSema is a new once-a-week injection that combines two medicines:

  • Semaglutide (the same ingredient in Wegovy)

  • Cagrilintide (similar to the hormone amylin, which reduces hunger)

How does CagriSema work?

It targets hunger and digestion by copying two hormones to:

  • Reduce your appetite

  • Help you stay fuller for longer

How effective is it?

  • People with type 2 diabetes lost around 15.7% of their body weight

  • People without diabetes lost up to 22% over about 1 year

Type 2 diabetes is a condition where your body has trouble using sugar properly, causing high blood sugar levels.

Are there other health benefits?

Yes — it may help people with diabetes manage their blood sugar while losing weight.

When will it be available?

It’s in the final testing stages and could be available by 2026–2027.

Young woman taking a weight loss pill with water, representing the emerging pill-based weight loss medications like CagriSema.

A Weight Loss Pill from Eli Lilly

Orforglipron

What is Orforglipron?

Orforglipron is a new daily weight loss pill from Eli Lilly. It’s exciting because it’s not an injection — just a tablet.

How does Orforglipron work?

It works by copying a hormone called GLP-1, which:

  • Makes you feel full faster

  • Helps your body control blood sugar

How effective is it?

  • People without diabetes lost up to 14–15% of their body weight in 9 months

  • People with diabetes lost 8–10% in 6 months

Are there other health benefits?

Yes — it can also help lower blood sugar in people with diabetes.

When will it be available?

It’s in the final stage of trials and may be available by 2026.

Young woman administering an injection into her abdomen using a KwikPen-style injector, showing self-use of weight loss medication.

A Once-a-Month Weight Loss Injection

MariTide

What is MariTide?

MariTide is a once-a-month weight loss injection being tested by Amgen. Instead of a weekly injection, this one only needs to be taken once every 4 weeks.

How does MariTide work?

It does two things:

  • Activates GLP-1 (a hormone that makes you feel full)

  • Blocks another hormone called GIP, which might help your body burn fat better

Unlike most medications that turn GIP on, this one turns it off — and it still worked well in studies.

How effective is it?

  • People without diabetes lost up to 20% of their body weight in 1 year

  • People with diabetes lost around 17%

Even better — people were still losing weight after a year. The results hadn’t flattened out yet.

Are there other health benefits?

Yes — it may help with blood sugar control, and the once-a-month schedule could be more convenient.

When will it be available?

It’s moving into the final trial stage. If all goes well, it could be available by 2027–2028.

Smiling man holding up a blister pack of pills, symbolising the daily pill format of orforglipron and future oral GLP-1 medications.

Another Promising Daily Pill

GSBR-1290

What is GSBR-1290?

GSBR-1290 is a daily pill being developed by Structure Therapeutics. It’s another potential option for people who prefer tablets over injections.

How does GSBR-1290 work?

It works by copying the hormone GLP-1 to:

  • Reduce appetite

  • Help control food intake and blood sugar

How effective is it?

  • People lost around 6% of their body weight in just 3 months

  • Some lost 10% or more in that short time

This is similar to early results from injectable weight loss drugs.

Are there other health benefits?

So far, the pill looks safe and may improve blood sugar levels. Side effects have mostly been mild (like feeling a bit sick or bloated).

When will it be available?

It’s still in middle stages of testing and may be available in the late 2020s.